Top Best Biotechnology Startups

[ ] 27/08/2019

1. NOTABLE LABS – Best Overall Biotech Startup

2. Transcriptic – Best On-Demand Lab Testing for Scientists

3. Science Exchange – Best Outsourced R&D Labs

4. Codiak BioSciences – Best Biotech for Cellular Modeling

5. Experiment.com – Democratizing Scientific Studies for the World.

6. Spero Therapeutics – Best Cell Therapeutics startup.

7. Neurable Labs – Best Brain Science Startup

8. Counsyl – Best Genetic Screening & DNA Testing Startup

9. Perlstein Lab – Best CRISPR/DNA Tech Startup

10. Semma Therapeutics – Best Diabetes and Insulin Biotech Startup

Our mission at Semma is to cure type 1 diabetes (T1D), which affects over 1.5 million people in the US alone. T1D is an autoimmune disease in which the insulin-producing beta cells of the pancreatic islets are unable to provide enough insulin to the body to keep blood sugar levels in the normal range. Symptoms of high blood sugars may include increased thirst and urination, weight loss, blurry vision, hunger, and weakness. If untreated, T1D may rapidly lead to death.

The mainstay for the treatment of T1D is the injection of exogenous insulin. Patients treated with too little insulin will lead to high blood sugars (hyperglycemia) and those treated with too much insulin may exhibit low blood sugars (hypoglycemia). Even with insulin treatment, persons with T1D are at risk for long-term complications of the disease including diabetic retinopathy and macular edema that may lead to blindness, diabetic nephropathy that may lead to kidney failure, diabetic neuropathy that may lead to loss of sensation or pain and puts patients at risk for unrecognized injuries, and vascular disease that may lead to ulcerations, amputations, heart attack, and stroke.

With the discovery of insulin a century ago, the disease was transformed from a rapidly fatal one to a chronic one. T1D is now one of the most common chronic diseases of childhood. However, the fundamental approach of managing the disease with exogenous insulin has not changed for most people with T1D. Better insulin formulations, insulin delivery methods, and monitoring technology have led to improvements in clinical outcomes for many, but the personal and family burden of disease management remains heavy.

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